Coming in 2nd in the villain-collection countdown is my favorite superhero, Spider-Man. His cast of bad guys is most definitely one of the best, and is surely one of the most colorful. His villains tend to not be massive level threats, but rather smaller-scale ones that often focus their evil deeds directly at Spider-Man himself. Also one distinction Spidey has over other heroes is that it could be argued that he has two nemeses.
The most vicious, personal, and psychologically damaging among his rogues gallery is the Green Goblin. Norman Osborn was the first villain to learn Spider-Man’s secret identity, and has continually used that knowledge to torture Peter Parker ever since. Brilliant both in science and tactics, and given enhanced strength and durability (but driven insane) by an experiment gone wrong, the Green Goblin attacks Spider-Man and his family on all fronts, and is responsible for arguably the defining moment of Spidey’s life: the death of his first love, Gwen Stacy.
Almost on par with the Green Goblin is Dr. Octopus. He has been Spider-Man’s most consistent enemy having made his first appearance in just the third issue of Spider-Man’s solo comic, and has been wreaking havok on him continually since. Equipped with mechanical arms that he can control telepathically, Otto Octavius is almost singularly obsessed with killing Spider-Man, even once saving him from another villain that was about to kill him, just so he could kill Spidey himself. The history between Doc Ock and Spidey became even more entwined when their consciousnesses were swapped and Ock was dying. Inside Peter’s body he swore to be an even better Spider-Man, but ultimately failed as he didn’t hesitate to kill criminals instead of bringing them to justice.
As part of his obsession with defeating Spider-Man once and for all, Dr. Octopus formed the Sinister Six, a super group of some of the Wall-Crawler’s greatest foes. Though the line-up has changed throughout its history, the team usually consists of: Electro (ability to shoot and control lightning), Mysterio (expert illusionist and effects specialist), Sandman (body composed of shape-shifting sand), Vulture (brilliant criminal with a bodysuit equipped with wings), Kraven (the world’s greatest hunter who sees Spider-Man as the “ultimate prey”), and lead by Doc Ock. Spider-Man typically requires help from other heroes to defeat the Sinister Six.
After Spidey manages to remove the Symbiote that had become his black costume, the Symbiote falls onto Eddie Brock, a humiliated reporter that Spider-Man had proved a fraud. Their combined hatred for Spider-Man and Brock’s cancer-ridden body producing extra adrenaline (which the Symbiote feeds on) come together to form a new and totally vicious entity known as Venom. With full knowledge of literally everything about Peter Parker, the ability to block Spidey’s Spider Sense, and a twisted sense of morality, Venom immediately becomes a major threat to everyone in Spider-Man’s life.
When the offspring of the Symbiote is left in Eddie Brock’s prison cell after his escape, it bonds with his cellmate, the psychopathic serial killer Cletus Kasady. Fueled by hatred for its “parent” and Kasady’s psychosis, Carnage is born. Breaking free and going on brutal killing spree, it took a truce between Spider-Man and Venom to defeat him. Even after his initial defeat, Carnage has continued to be a sadistic thorn in the side of the Web-Slinger.
When biologist Curt Connors experiments on himself with reptile DNA in an attempt to regenerate the right arm he lost in the military, he is instead transformed into the mindless reptilian monster simply known as The Lizard. He eventually changes back, but will occasionally revert back to his monstrous form without warning. His story is one of the more interesting of Spider-Man villains, as Spidey is stuck trying to stop The Lizard’s deadly rampages but also trying to do so in a way that doesn’t permanently harm Connors.
Biochemist Michael Morbius attempted to cure himself of a rare blood disease by experimenting on vampire bats, he inadvertently gave himself a form of “psuedo-vampirism” where he must subsist on human blood in order to survive and gains superhuman strength, reflexes, durability, and the ability to fly. His appearence also changes to resemble that of a bat, becoming known as Morbius the Living Vampire. His need to feed has set him at odds with Spider-Man on multiple occasions.
While J. Jonah Jameson may not be the type of character you think of when you’re discussing a hero’s rogues gallery, but he has been every bit as big of a thorn in Spider-Man’s side as anyone else. Being Peter Parker’s boss at the Daily Bugle means that Peter has to listen to Jameson’s constant hate-filled defaming of Spider-Man on a daily basis. Jameson hasn’t settled to just attempt to destroy Spider-Man’s reputation through the media, but has also been behind several supervillains’ attempts at killing Spidey, including being responsible for the creation of major Spider-Man villain, The Scorpion.